P10: Effects of Female Gonadal Hormones on Neuromedin S and its Receptor Following Experimental Traumatic Brain Injury
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p10: effects of female gonadal hormones on neuromedin s and its receptor following experimental traumatic brain injury
brain edema plays an important role in secondary tissue damage following traumatic brain injury (tbi) but the underlying mechanisms are not entirely elucidated. the g protein coupled receptor fm-4 and its ligands, neuromedin s (nms) and neuromedin u (nmu), are expressed in diverse brain areas, and have a variety of roles in nociception, inflammation, and stress but their probable changes after ...
متن کاملEffects of sex steroid hormones on neuromedin S and neuromedin U2 receptor expression following experimental traumatic brain injury
Objective(s): Neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (TBI). Two of these peptides are including the regulatory peptides neuromedin U (NMU) and neuromedin S (NMS), and their common receptor neuromedin U2 receptor (NMUR2). This study investigates the effects of physiological do...
متن کاملeffects of sex steroid hormones on neuromedin s and neuromedin u2 receptor expression following experimental traumatic brain injury
objective(s): neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (tbi). two of these peptides are including the regulatory peptides neuromedin u (nmu) and neuromedin s (nms), and their common receptor neuromedin u2 receptor (nmur2). this study investigates the effects of physiological do...
متن کاملEffects of sex steroid hormones on neuromedin S and neuromedin U2 receptor expression following experimental traumatic brain injury
OBJECTIVES Neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (TBI). Two of these peptides are including the regulatory peptides neuromedin U (NMU) and neuromedin S (NMS), and their common receptor neuromedin U2 receptor (NMUR2). This study investigates the effects of physiological doses...
متن کاملThe Effects of Female Sex Steroids on Gastric Secretory Responses of Rat Following Traumatic Brain Injury
Objective(s) Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. The female sex has more resistance to stress and the gastrointestinal lesions happen fewer than male sex. The purpose of this study was to evaluate the role of estradiol and progesterone on the gastric acid and pepsin levels following traumatic brain injury (TBI) induction. Materials and M...
متن کاملChanges in neuromedin S and its receptor after traumatic brain injury in cycling rats
Animal studies indicate that gonadal steroids have prominent neuroprotective effects in several models of experimental traumatic brain injury (TBI). Neuromedin U (NMU) and neuromedin S (NMS) are regulatory peptides involved in inflammatory and stress responses, and modulation of the gonadotropic axis. Since steroid hormone levels change during the estrous cycle, we sought to determine whether v...
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عنوان ژورنال
دوره 2 شماره 4
صفحات 60- 60
تاریخ انتشار 2014-12
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